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Recent reports, including serologic surveys and experimental infections, indicate that raccoons can be symptomatically or asymptomatically infected with low pathogenic influenza viruses, such as avian influenza subtype H4N8 or human influenza subtype H3N2 viruses, which they shed for several days, resulting in virus transmission to other raccoons by aerosol (3 – 5 ).
Data from US malaria therapy patients who received two P. vivax infections indicate that immunity against re-infection with the homologous P. vivax strain is acquired very rapidly.
These infections indicate the presence of HIV-related risk behaviour, as well as biologically enhancing the transmission and acquisition of HIV itself[12], [13], [14], [15], [16], [17], [18], [19].
In particular, the emergence of drug resistant strains of Mycobacterium tuberculosis (MDR- and XDR-TB) and the increased occurrence of methicillin-resistant Staphylococcus aureus (MRSA) infections, indicate that drug resistance is a major public health problem [1], [2].
The results of the evolution experiments with mixed infections indicate a rapid switch in population composition where the genotype with higher multiplication rate and hypovirulent outcompetes the hypervirulent one but with lower multiplication rate.
A number of studies on persistent murine and human viral infections indicate that virus specific CD4+ T cells play a critical role in the outcome of viral infections [6], [7], [8], [9], [10], and are required to maintain effective cytotoxic T cell responses [11] and neutralizing antibodies [12].
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Recent empirical studies [21] suggest that asymptomatic infections are more infective than clinical infections, indicating that φ>1.
Mathematical modeling of scaling up the proven non-treatment related prevention methods such as condom use and adult male circumcision at the same time as scaling up treatment of infected individuals (and thus preventing even more infections) indicates that a tipping point could be achieved and the trajectory of the pandemic dramatically altered.
The increasing risk of drug-resistant bacterial infections indicates that there is a growing need for new and effective antimicrobial agents.
Moreover, analysis of the parasite population structure suggested little out-breeding with few polyclonal infections, indicating low transmission.
Mixed infections indicated that the B-repeat region plays a key role in virulence, as expected from its essential role in phagocytosis resistance [21], [22], [25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com