Champion, O.L. et al. Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.
Conclusions: Known HIV infection, source of household income, time required to fetch water, and severe household food insecurity were independently associated with reported history of medically attended cholera in HIV-affected households in rural Haiti.
Similarly, P4 peptide treatment significantly increased neutrophil and monocyte intraphagosomal reporter bead association and oxidation, independent of infection source.
Results P4 peptide increased neutrophil killing of opsonised pneumococci by 8.6%% (C.I. 6.35 - 10.76, p < 0.001) in all phases of sepsis, independent of infection source and microbiological status.
In longitudinal models adjusting for demographics, comorbidities, and infection source, older age was associated with higher baseline values for chemokine (CC-motif) ligand-23, interleukin-1 receptor antagonist, NGAL, and TNFR-1a (all P < 0.05).
These removed 99.9% or more of viable bacteria, and no E. coli (a common infection source) were detected after use.
Epidemiological investigations have clearly defined detailed transmission among those patients, showing each of the group came from one super spread chain arising from one infection source.
The infection source did not predict mortality.
Epidemiological investigation suggested a common infection source.
First, the control and management of infection source were enhanced.
Infection source can determine cost-effective public health interventions.
