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However, their relative fitness was not related to their natural infection status, and within a population cured but formerly infected animals were not generally worse competitors as suggested by the inbreeding infection hypothesis (Fig. 2 4).
But Dr. Brian A. Fallon, a psychiatrist at Columbia University and director of the Lyme Disease Program at the New York Psychiatric Institute in Manhattan, said that despite the Klempner study, which he described as important and illuminating, it was too soon to give up the "persistent infection" hypothesis.
At the same time, Mel Greaves postulated a "delayed infection" hypothesis, according to which the development of leukemia is partly caused by an abnormal immune reaction to a common infectious agent [9].
Still, "this is a very important piece of the jigsaw puzzle," says Crohn's researcher Robert Greenstein of the Veterans Affairs Medical Center in New York City, a supporter of the infection hypothesis.
The Greaves' delayed infection hypothesis.
They called this the 'binary infection hypothesis'.
Similar(30)
As with CVD infection hypotheses, chronic inflammation in response to periodontal bacteria might link periodontal disease and type 2 diabetes.
In contrast, the inbreeding-infection hypothesis predicts that formerly infected genotypes are those that are also more inbreed and thus should have a lower fitness compared to the naturally uninfected genotypes.
The inbreeding-infection hypothesis postulates that cured but formerly infected genotypes should have a lower fitness compared to naturally uninfected genotypes.
Likewise, there is no evidence that naturally infected genotypes are generally poor competitors as predicted by the inbreeding-infection hypothesis.
Therefore, our data do not support the inbreeding-infection hypothesis.
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