Exact(51)
The serial interval was calculated by determining the time between the event when an individual became infected, and subsequent infection event due to that individual infecting another, averaged over all infected individuals during a simulation run.
We performed Monte Carlo ensembles of stochastic dynamic simulations operating on the contact data, where the primary variables drawn from distributions were disease stage durations, exogenous infection event rates and the probability of transmission from infected endogenous contacts.
"The beauty of it is that for every infection event, for every time a virus enters a cell, it is also an opportunity for the antibody in the cells to take the virus out," Dr James said.
Regarding symptomatology in these patients, most of them presented with dyspnoea or a respiratory infection event.
The following were significantly associated with ICU mortality in the univariate analysis: the need for respiratory assistance, the use of vasopressors, the occurrence of at least one infection event in ICU, cyclophosphamide treatment, sequential organ failure assessment at admission and simplified acute physiology score II.
In essence, the approach is to use lazy evaluation for large groups of pairs with similar probabilities of an infection event.
Similar(8)
Infection events were reported in 40% of the patients during the ICU stay, with an identified pathogen in 82% of them.
In a multivariate logistic analysis, cyclophosphamide was no longer associated with mortality after adjustment on SAPS II or occurrence of infection events (Additional file 3: Table 3).
In deriving the correction factor, McDougal et al. assume uniform infection events over the window periods.
In these settings the incidence of infection events involving casual contacts can be regarded as insignificant.
This is a consequence of the deferral of infection events for such a vaccine.
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