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To track potentially infected farms from a given source, the infection chain was proposed by Dubé et al. [ 8].
We quantified virus transmission in homogenous groups of vaccinated or non-vaccinated pigs in which the infection chain was started by exposure to a third group of non-vaccinated infected pigs.
The epidemiologists, in turn, were able to swiftly allocate resources to households and villages in the infection chain.
The Red Cross said the new hotspot seems to have started from an "imported case" and contact with a family who "refused to believe their parents had Ebola", setting in train a deadly new infection chain.
In the district of Koinadugu, where an infection chain started three weeks ago when a man carrying the virus returned to the remote chiefdom of Niene, the Red Cross on Monday said the number of dead had increased in recent days.
Hesaid district leaders were "hesitant about celebrations": there remained a high risk that a new case would come from a neighbouring district, or from Liberia, and begin a new infection chain.
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The main strategy for outbreak management focuses on the reduction of secondary transmission by isolating infected individuals, the implementation of safe burial practices, contact tracing to disrupt infection chains, and education of the local population regarding risk reduction [ 6].
"The outbreak is far from over, as a single case can start a localised epidemic," it said, reporting infection chains starting in remote rural areas with no access to treatment centres or testing facilities.
HIV spreads through often complex contact networks or transmission (infection) chains [26], [27].
Although infections secondary to imported cases may be frequent, especially in the immediate vicinity (household, family) of a case-patient, infection chains quickly terminate.
So far, genetic analysis of HAdV-A31 strains isolated from hSCT patients showed significant differences even in the same clinical centre, suggesting reactivations rather than infection chains of de novo HAdV-A31 infections [ 14, 22].
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