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Data on the initial site of infection and the infecting microorganisms (based on infection site and blood culture) were collected periodically.
In general, coagulase-negative staphylococci, S. aureus, and P. acnes are the most common infecting microorganisms implicated in shunt infections [ 89].
Insects commonly transmit the infecting microorganisms and provide the entry wounds.
The infecting microorganisms cultured are shown in Tables 1 and 2. Some joints had more than one microorganism.
Changes in metabolite concentrations in CSF samples are due to a combined effect of metabolites from infecting microorganisms, inflammatory cells and changes due to the effect of meningitis on brain cell metabolism.
In addition, overcrowding and poor hygiene favour the interchange of infecting microorganisms.
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The serum bactericidal test performed in good conditions is useful to monitor the interaction between serum (anti-microbial and host response) and infecting microorganism in severe infections.
Prevention and treatment of specific infections in these patients should be dictated by knowledge of the infecting microorganism and its sensitivity to antimicrobial agents, as well as the disruption of gut microflora balance during antibiotic treatment.
Most common infecting microorganism was Staphylococcus aureus.
In ICU patients, empirical use should be avoided, and definitive therapy should be reserved to patients in clinical stable condition, after microbial documentation and results of susceptibility tests, together with adapting the administered dose and modalities of infusion to the MIC of the infecting microorganism in order to reach pharmacological targets.
In turn, chemokines are required for the recruitment of neutrophils into airways which is a common histological finding in patients with pneumonia, independently of the infecting microorganism [9].
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