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Perinatal information on the mother and infant were extracted from their medical charts including sex, gestational age, birth weight, mode of delivery, duration of hospitalization, maternal age, parity, gravidity, maternal blood type, family history of siblings, and feeding type before and after discharge.
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For pregnancies yielding more than one birth (ie, twins or more), only the birth record for the first-born infant was extracted.
The birth weights of the infants were extracted from the maternity records.
Reports for maternal and paternal CZP exposure were included and outcomes examined, and data on CZP exposure, pregnancy, comorbidities, and infant events were extracted by 2 independent reviewers.
Infant formula samples were extracted with 1 1 acetonitrile water, cleaned up on disposable ion-exchange solid-phase extraction cartridges, and analysed by ultra-high-performance liquid chromatography-tandem mass spectrometry.
12 Infant medical records were extracted from birth to age 1 year using the Secure Anonymised Information Linkage (SAIL) databank developed at Swansea University.
Data concerning subject demographics, birth and disease characteristics, disease outcome, maternal and infant antibiotic use were extracted from medical records and/or parental/guardian interviews following subject enrollment.
For the preterm infants, the miRNAs were extracted from whole blood because of the small volume of blood collected (less than 500 μL).
39 Infant birth weight and gender were extracted from medical records by the District Health Boards/Ministry of Health through matching on the infant's national health index number and birth date.
Data were extracted from infants' medical records, and the women completed questionnaires.
Detailed data on the neonate were extracted on infants admitted to the neonatal unit including details on ventilation, suspected neonatal abnormalities including Fetal Alcohol Syndrome FASS) and neonatal death.
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