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The first was 0-5 years old group, which was sub-grouped into the <12 month-old infant group and the 1-4 year old group.
Among all patients, the highest frequency of metastatic disease at diagnosis was found for Group 3 (30%) and Group 4 tumors (31%) and these percentages were even higher in the infant group (47 and 36%, respectively) (Fig. 1m p).
Additional trends and significant associations seen within the infant group again involved KIR2DL2 and KIR2DL3.
Thirty-three different genotypes were detected in the mothers and 35 in the infant group, with a total of 46 different genotypes detected in the combined mother-infant group.
This comparison reveals a statistically significant (p = 0.01) overall haplogroup difference only in comparison with the infant group.
The INF infant group also had significantly lower representation of the combination of homozygous KIR2DL3 and heterozygous HLA-C allotype group i.e. C1C2 (P = 0.038; OR = 0.40).
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Both infant groups learned to look at that side of the screen in anticipation of the puppet.
Although studies have previously described the cost-effectiveness of palivizumab in high-risk infant groups [12 15], the conclusions have varied and concerns have been raised regarding the data and assumptions used within these analyses [18].
While this is the case for some subgroups in this analysis, it is not the case throughout given the relatively low base case mortality rates assumed, especially for the preterm infant groups.
The mother and infant groups were tested separately.
There were no significant differences in comparisons of these frequencies within the mothers or infant groups.
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