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It is inherited in an autosomal dominant manner and is characterised by hyperuricaemia and gout, inevitably progressing to end-stage renal failure.
In this view, stem cells differ from transit amplifying progenitor cells, which may be multipotent and are capable of self-renewal, but are not halted at an intermediate position, hence inevitably progressing towards terminal differentiation.
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CAC nearly inevitably progress, with limited influence of traditional risk factors, so prediction or calculation of progression of CAC might be important [ 25, 27].
It bothers me that one day, when his disease inevitably progresses, he will blame me for concealing the truth.
Darwin's critics believed, for example, that species inevitably progress toward more and more complex forms, a fashionable yet fallacious idea of the mid-19th century.
It is speculated that loss of chondrocytes is a key step in the development of arthritis; without cells to maintain the cartilage matrix, the joint inevitably progresses to osteoarthritis.
It is speculated that loss of chondrocytes may be an essential step in arthritis [12], i.e., without chondrocytes to maintain the matrix, the joint inevitably progresses to end-stage arthritis.
Nonetheless, some continue to argue (e.g., Wright 2001) that life, and humanity in particular, inevitably progresses in this ratcheting fashion due to the steady accumulation of ordered, directed change.
As coal resources become exhausted in shallow mines, mining operations will inevitably progress from shallow depth to deep and gassy seams due to increased demands for more coal products.
Without treatment, patients inevitably progress to coma and death.
For non-responsive LN patients, they will inevitably progress to end-stage kidney disease.
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