This strategy has shown to result in significantly higher sensitivity for lesions of ≥6 mm and although specificity inevitable decreases, it does not do so significantly [ 75, 80].
Polymerase chain reaction (PCR -based techniques that amPCR -basedhelial mRNA are more sensitechniqueseed thatintroduction of cut-off vamplifyor positivity to correpitheliale inevitable loss of specificity.
Although the relative insufficiency of their specificity is inevitable, based on the nature of living systems, microbial cell arrays can provide unique data on the global activity of test samples with a range of advantages that are not achievable using other analytical methods.
Clearly, it is not possible to obtain individual tap water samples at each maternal residence, or direct measures of individual exposure, in such a large-scale study, and there is an inevitable trade-off between specificity of the exposure assessment and study power.
Therefore, the use of whole cells as sensing entities can conveniently provide a diverse array of data on integrated biological effects that cannot be achieved using other biosensors, although the relative insufficiency of their specificity is inevitable, based on the nature of living systems.
Of course there is an inevitable trade-off between sensitivity and specificity and the balance within our algorithm may already be optimal.
We have deliberately chosen to emphasize overall performance here with balanced accuracy or AUROC because while certain models may have demonstrably superior sensitivity, others had better specificity, thus illustrating the inevitable trade-off effect between sensitivity and specificity.
This leads to an inevitable breakdown of the strict thermodynamic and specificity criteria that are usually imposed on the design of an expression microarray.
This difference can be probably explained by specificity of PS nanoparticle synthesis resulted in inevitable presence in their composition of SLS impurity which in turn changed the PS thermal behavior.
Finally, if expression levels rather than allele differences are used as predictors of cognitive processes, then inevitable questions for study replication arise concerning the lack of sensitivity and specificity of various array gene expression chips compared to RT-PCR.
