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The material of choice for such applications is silicone, an inert synthetic biomaterial which elicits a minimal chronic foreign body response (FBR).
They are chemically and biologically inert synthetic molecules [11].
Polypropylene is known as an inert synthetic material with good integration, being the most used synthetic graft material.
29 Polymethylmethacrylate (PMMA) is an inert, synthetic permanent filler material that induces fibrous capsule formation in animals.
Perfluorochemicals are chemically inert synthetic molecules that consist primarily of carbon and fluorine atoms, and are clear, colourless liquids.
Chemical modification of inert, synthetic polymers with DOPA and its derivatives (e.g., dopamine) has led to the development of various adhesive biomaterials for soft tissue repair, drug delivery, and antifouling coatings.
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TISA process could readily blend PCL with PLA, leading to increased osteogenic capabilities in vitro, however, these bio-inert synthetic polymers produced limited BMP2-induced bone formation in vivo.
In tissue engineering, regenerative medicine and many other biomedical fields, surface engineering of the bio-inert synthetic polymers is often required to introduce bioactive species that can promote cell adhesion, proliferation, viability and enhanced ECM-secretion functions.
To induce cellular infiltration into inert and synthetic hydrogels, hydrogels are typically modified with cell-binding peptides (e.g., RGD) or other bioactive protein or are designed to be susceptible to matrix metalloproteinase-mediated degradation, which requires complicated and multistep chemical synthesis.
It focuses on synthetic inert prostheses (keratoprostheses), acellular scaffolds with and without enhancement of endogenous regeneration, and cell-based replacements.
The authors developed a new synthetic inert masked MK801 derivative that can be "unmasked" and activated inside the cells that have been previously successfully transfected with a virus that allowed the expression of the fundamental catalytic enzyme porcine liver esterase (PLE).
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