This was suggestive of the formation of intracellular aggregates and indicated that the heterologous expression ensued in inefficient trafficking to the plasma membrane.
It is possible that such dual localization [19], [22] is a consequence of inefficient trafficking of recombinant fusion proteins, as previously suggested [51].
This may be attributable to inefficient trafficking through the secretory pathway (perhaps as a consequence of expression timing and/or recombinant protein fusion), protein-protein associations, unusual subcellular targeting signals, or other factors.
On the other hand, inefficient trafficking of immune cells may eliminate important mechanisms needed for control of viral replication and clearance of virus from the CNS which appears to be an early protective response.
We can hypothesize that fragmentation of the mitochondrial network in Afg3l2-depleted PCs causes defective mitochondrial Ca2+ buffering, but also inefficient trafficking of the organelles to dendritic stalks and distal branches.
Guanidinylated polymers disrupted function of isolated mitochondria more than their lysine-based analogs, but overall toxicity was decreased, likely due to inefficient mitochondrial trafficking.
This supports the idea that when ΔF508 CFTR is inefficient in trafficking, there is exaggerated NFκB mediated signaling due to lack of gap junctional communication (GJIC) of CFTR with TNFα or IL1-β receptors.
Thus the defect of age3Δ cells to maintain the balance of polarized versus isotropic growth, which is required to sustain true hyphal growth after germ tube formation, is probably a combination of disturbed polarization of the actin cytoskeleton and inefficient vesicle trafficking.
Although TCP-DDA has shown a good performance in static ad hoc networks compared to the standard TCP, it may be inefficient in high traffic scenarios with considerable packet loss.
Still, Kerry is right that the prosperous, urban side of India, with a straining, highly inefficient electrical grid, traffic-choked streets and other sources of energy waste, can do plenty to cut emissions even as it boosts energy access.
