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Several open-loop DBS control strategies have been developed for clinical experiments, but they are limited by short battery life and inefficient therapy.
The diagnosis of baseline resistance in individual patients could improve the cancer treatment by the avoidance of inefficient therapy.
Therefore, the pretherapeutic identification of non-responding patients would be valuable and help patients avoid inefficient therapy, toxic side effects and costs.
The accurate assessment of response to therapy is essential for identifying non-responders and avoiding inefficient therapy and its potential side effects.
Inherent resistance, ligand-independent ER signalling and inefficient therapy could all be associated with a molecular phenotype in which the expression of oestrogen-regulated and proliferation-associated genes do not change markedly with treatment.
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We now hypothesize that in 2006 the patient was infected with A. lentulus, which could not correctly been identified morphologically, and that inefficient antifungal therapy for the causative A. lentulus may have allowed progression.
Unfortunately, iPS cell cardiomyocyte differentiation ratio is extremely inefficient for therapies, much like ES cells [26].
These drawbacks together with low diffusivity render the real application of stem cell therapy inefficient due to the ineffective delivery and non-specific distribution.
Local myotoxicity in accidents involving snakes from the Bothrops genus is still a consequence of serum therapy inefficient neutralization that may lead to permanent sequelae in their victims.
The administration of suboptimal chemotherapeutic concentrations, active only for planktonic forms, not the main infection factor, may be inefficient for pharmacological therapy.
Predictors for poor post-interventional flow in the coronary arteries are three vessels disease, cardiogenic shock, diabetes mellitus, and inefficient prehospital thrombolytic therapy.
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