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Further analysis by CASC5 siRNA knockdown in HeLa cells revealed chromosomal misalignment and the premature entry of the cells into mitosis; this defect causes improper symmetrical and asymmetrical division, which results in inefficient proliferation, inappropriate neuronal number and abnormal brain size [ 45].
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Furthermore, a high level of chromosomal instability inhibits tumour growth, probably owing to inefficient cell proliferation or apoptotic induction (Weaver et al, 2007; Garcia-Higuera et al, 2008).
Proliferation of inefficient equipment and desire to minimize initial cost.
The inefficient re-induction of proliferation in adult cardiomyocytes may be due to the epigenetic landscape, which drastically changes during cardiac development and maturation.
In the brief interim before the fall of Shanghai to the People's Liberation Army PLAA) of the Chinese communists in 1949, the city's economy suffered even greater dislocation through the haphazard proliferation of small, inefficient shop industries, rampant inflation, and the absence of any overall plan for industrial reconstruction.
The CSP disorderly proliferation propitiated by inefficient control mechanisms has resulted in an overrun cost to the electricity system that has tried to be mitigated with the application of retroactive measures seriously harmful for the investors.
"Although the acquired confectionary businesses strengthened Cadbury's global foothold, allowing these businesses to run with a high degree of autonomy, it gave the firm a bloated management structure, too many inefficient manufacturing plants and a proliferation of stock-keeping units and innovation projects that added unneeded complexity," said Morningstar analyst Erin Swanson in a recent report.
Interestingly, PVB behaved in a manner similar to doxorubicin despite the fact that PVB is an inefficient inhibitor of MB cell proliferation [ 12].
Tumor cells both require more energy for their higher proliferation rate and utilize the inefficient glycolytic pathway to produce energy.
Ample literature has demonstrated dysfunction of regulatory T cells in SLE, with SLE regulatory T cells being inefficient suppressors of inflammation and T-cell proliferation [ 85, 86].
On the other hand, lepromatous leprosy (LL) presents as many skin lesions with uncontrolled proliferation of leprosy bacilli and inefficient CMI.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com