The other extreme is represented by the formation of cytosolic and nuclear inclusion bodies due to inefficient degradation of aberrant proteins by the ubiquitin proteasome system.
Hence, notwithstanding criticism that its inclusion would serve to reinforce inefficient provision practices, NSW places considerable weight on geographical remoteness in the needs component of its formula [ 26].
The presence of misfolded protein inclusions suggests that autophagy is inefficient or dysfunctional in ALS and there is increasing evidence for this notion.
The main strength of the present study is inclusion of a placebo limb using an inefficient nebulizer system.
In general, such platforms are either highly capital-intensive mammalian cell cultures based on secreted proteins [ 2], or require complex and inefficient refolding of bacterially expressed proteins sequestered in insoluble inclusion bodies [ 3].
Examples are the inclusion of unnecessary waiting times, enrollment constraints, grouping of students, inefficient temporal organization of the curriculum, the degree of flexibility in tempo, etc.
The inclusion of inelastic biomass in the energy/material input to economies makes those who are consuming less fossil fuels seem inefficient in comparison with their richer counterparts.
Still, it is inefficient.
