In contrast to the D159 variant, another variant of L1spa that encodes ORF1p with a histidine codon (H159) at this position is known as a retrotransposition-inefficient element [ 121].
Likewise, reductions in genomic repetitive element proportions are observed in small genomes, potentially as a result of reductions of inefficient genomic elements while maintaining a functional gene complement [ 31, 34, 49].
The reason for this is the presence of one of two particularly inefficient operator elements: L2 at the upstream position (F2, F6, F26) and the presence of a single λ operator at the downstream position (F10, F11, F14).
After considering about 20 models, the Sweethome decided that almost any mini-fridge will get the job done, so long as it has a real compressor (opposed to an inefficient thermoelectric cooling element) and has only one door (for consistent temperatures).
Current models discretized using micro-models, or finite elements, are computationally inefficient for large structural systems, such as bridges or buildings.
The road to reform was not easy, as conservatives, supported by foreign powers, opposed most of the changes, attempting to defend liberum veto and other elements perpetuating the inefficient governance, most notably through the Cardinal Laws of 1768.
PCR through the secondary structure of the ITR is inefficient and sequencing through these elements typically requires radiolabeled chain-terminator sequencing [13].
Transcription of endogenous L1 elements is generally inefficient but there are a small number of highly active "hot L1s", which were used to generate a transgenic mouse model of L1 retrotransposition that showed a higher frequency of de novo somatic L1 insertions [269].
For example, it would take more than a century to destroy half of the radioactive selenium present in spent fuel, because that element is very inefficient at capturing neutrons.
Whereas accessing elements along a column is inefficient as distant memory elements have to be fetched from different cache lines.
