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The therapeutic efficacy of nanoscale anticancer drug delivery systems is severely truncated by their low tumor-targetability and inefficient drug release at the target site.
Iron oxide nanoparticles (IONPs), with their advantages of being non-toxic, biodegradable and inexpensive, are candidate platforms for the buildup of theranostic nanostructures; however, progress in using them has been limited largely due to inefficient drug loading and delivery.
Importantly, the relationship between delivery and therapeutic efficacy has proved elusive, owing to inefficient drug release from nanocarriers and/or target site access resulting from physical or physiological hindrance.
Certain issues with the use of particles of chitosan (Ch) cross-linked with tripolyphosphate (TPP) in sustained release formulations include inefficient drug loading, burst drug release, and incomplete drug release.
Let the pharmaceutical industry develop Viagra-like medications but let's use tax money wisely and expand the National Institutes of Health to develop life-saving medicines and treatments at a small fraction of the cost of the bloated, inefficient drug industry.
As a young cancer researcher at MIT in the early 1990s, Friend visited drug firms and was shocked to see how inefficient drug discovery was.
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Collectively, these findings suggest that PDE5 may serve as an effective target for pharmacological modulation of BTB permeability to enhance delivery and therapeutic effect of otherwise inefficient drugs in the metastatic brain tumors.
Penicillin-G (12.5%) and streptomycin (9.4%) were inefficient drugs; gentamycin and vancomycin were totally inactive against both isolates.
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First, that its review processes are over-cautious and inefficient, driving up drug and product costs and causing delays that deprive consumers of potentially life-saving drugs.
This problem of inefficient and unpredictable drug release is compounded by the present lack of low-cost, non-invasive methods to measure such release.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com