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In summary, while atypical and classical MBCs appear closely related developmentally, atypical MBCs exhibit markedly reduced signaling and effector function, which may contribute to the inefficient acquisition of humoral immunity to malaria.
Thus, although the population genetic arguments above suggest that piRNAs may be more effective than CRISRPs at repressing their targets, this may be countered by their more inefficient acquisition mechanism.
Thus, while atypical and classical MBCs appear closely related, atypical MBCs exhibit markedly reduced signaling and effector function, which may contribute to the inefficient acquisition of humoral immunity to malaria, findings that point toward the possibility of modulating B cell responses to enhance malaria vaccine efficacy in endemic areas.
The inefficient acquisition of humoral immunity that protects from malaria has been attributed, in part, to the extensive genetic diversity of P. falciparum parasites (Takala and Plowe, 2009) and the extraordinary clonal variation in the proteins the parasite expresses on the surface of the erythrocytes that it infects (Scherf et al., 2008).
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Paper-based student evaluations suffer from low response rates, inefficient data acquisition and analysis, and difficulty obtaining input from multiple evaluators.
A number of saprotrophs obtain carbon from decaying plant matter, but this method of acquisition is inefficient for uncompetitive fungi.
Background: Developing technical skill is essential to surgical training, but using the operating room for basic skill acquisition may be inefficient and expensive, especially for laparoscopic operations.
Students with inattention are inefficient learners thus limiting their acquisition of basic skills necessary for higher education [ 11].
The phase-locked loop (PLL) method used in conventional time-division multiple access system is inefficient due to the very long acquisition time.
The reality is that barriers to clean energy development in India include problems with the country's grid infrastructure, high cost of financing, inefficiencies in power distribution companies and issues with land acquisition, continued dependence on domestically-produced coal, inefficient coal-fired power plants, and an inadequate grid.
"For mechanics, the parts acquisition process has always been intransparent and inefficient.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com