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12 Inducers of CYP3A4 activity, such as phenytoin or St. John's wort, decrease bromocriptine levels and can lead to ineffectiveness of therapy.
Those who utilize it have long standing conditions for which conventional medicine cannot provide effective relief, either due to ineffectiveness of therapy or because it causes adverse effects.
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Only 60% in the D arm completed the planned chemotherapy courses, mainly arising from the clinical ineffectiveness of the therapy.
The IL10 is secreted by a population of CD4+ T cells also secreting IFN γ, and these cells are most likely responsible for the ineffectiveness of Imiquimod therapy.
The immunohistochemical evaluation of proteins expressed in the different healing phases of PRP-treated skin may provide invaluable information to validate the effectiveness or ineffectiveness of the therapy.
In nine patents (12%) resternotomy was fulfilled because of ineffectiveness of rFVIIa therapy (bleeding rate 5 ml/kg/hour and more).
Indeed, if confirmed on larger samples, the finding that OxS level might not be crucial for the progression from MCI to LOAD might explain the ineffectiveness of antioxidant therapy in MCI patients [ 40].
Until that happens, the virtual ineffectiveness of standard therapies means that clinical trials — "warts and all" — hold the best promise for melanoma patients.
Age-related comorbid conditions, functional impairment, poor tolerability, ineffectiveness of available therapies, and patient/family preferences can all influence whether the physician recommends active treatment to a patient.
Considering the high mortality and ineffectiveness of current therapies for HCC, understanding the characteristics and function of CSCs is likely to lead to development of new therapies resulting in improvement of patient survival.
The overall 5-year survival rate is of only 15%, due to the long-term ineffectiveness of current therapies and late stage at time of diagnosis (Siegel et al, 2012).
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