Sentence examples for ineffective suppression from inspiring English sources

Lower expression of PD-1 in SLE lymphocytes could be related to ineffective suppression of autoreactive lymphocytes and thus to disease evolution.

However, despite the fact that isRNA displays immunostimulatory, antitumor, and antimetastatic properties, the lifespan of isRNA-treated mice was not significantly increased because of the ineffective suppression of primary tumor growth.

Insulin resistance occurs in >85% of patients and is associated with impaired insulin-mediated glucose uptake in insulin-dependent tissues (mainly skeletal muscle) and ineffective suppression of hepatic glucose production.

Furthermore, in the absence of confounding factors, effective inhibition of aromatase by third generation inhibitors appears to occur in most postmenopausal patients [ 59, 60], suggesting that ineffective suppression of oestrogen is only likely to be the cause of resistance in occasional cases.

In support of this observation, a previous study demonstrated that HIV infection caused the upregulation of a number of IFN-stimulated genes whose expression did not correlate with control of HIV replication, leading the authors to conclude that some IFN-α-induced genes were ineffective in viral suppression [30].

Taken all together, although TLR2 activation by Pam2 lipopeptides is able to induce inflammatory cytokines and activate NK cells in vitro [25], the systemic injection of Pam2 lipopeptides as cancer adjuvants is ineffective at abolishing immune suppression.

Surprisingly, the seizure suppression is ineffective with sda and eas mutants.

Moreover, plasma ACTH becomes biologically ineffective which leads to suppression of the synthesis and release of cortisol from ACTH-stimulated adrenocortical cells (Fig.  2) [ 20].

When compared to time-0 BZ, day-1 BZ was not just ineffective, but actually delayed BCR/Ablprotein suppression, indicating that hypoxia suppressed BCR/Ablprotein at least in part via proteasoma.

The persistence of infection leading to chronic tuberculosis may be due to an ineffective immune response that involves suppression of specific immune mechanisms [ 6].

Similar to their human counterparts, these animals have moderately severe, transfusion-independent hypochromic, microcytic anemia associated and ineffective erythropoeisis resulting in splenomegaly, hepcidin suppression, and secondary iron overload [ 4– 7].