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Each drug therapy preferably started with the minimum effective daily dose regimen, except for when a prior, ineffective regimen was already in the clinical records of the patient.
We choose optimal designs under the null hypothesis since we want to minimize the number of patients treated with an ineffective regimen.
Indeed, improved molecular characterization of subtypes such as TNBC may enhance the likelihood of treatment success, enabling therapy to be tailored from an ineffective regimen at an earlier stage [ 2].
Of those taking either no prophylaxis or an ineffective regimen, 64.2% took no prophylaxis, 6.7% took chloroquine, 15.4% took chloroquine and proguanil, 4.1% proguanil, 0.7% pyrimethamine, and 3.5% another regimen.
Cancer phase II trials are therefore designed to control the probabilities to continue with an ineffective regimen or to abandon an effective one (type I and II error rates, respectively).
Additionally, if accrual is fast, the total required recruitment could be completed by the time of the interim review, possibly resulting in more patients than necessary being treated with, what turns out to be, an ineffective regimen.
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Incorporation of novel trial designs that permit simultaneous evaluation of several agent combinations and allow for rapid discontinuation of ineffective regimens can accelerate the clinical evaluation of such candidate regimens.
MBL production is also in increasing trend causing the carbapenems to be the ineffective regimens.
Too little drug exposure leads to ineffective regimens, whereas too much creates the risk of adverse effects.
Ineffective regimens were those without supportive clinical trials data, without international guidelines, or not likely to work because of the drug-resistance pattern of the patient's isolate.
Since the efficacy of adjuvant interferon appears to be dose-dependent, it is possible that this trial compared two ineffective regimens.
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