However, these inhibitors are ineffective if used in the presence of mutations in EGFR downstream transducers, such as K-RAS, B-RAF, PI3K or phosphatase and tensin homolog deleted on chromosome 10 (PTEN) [ 15].
It seems possible to me that the Persians were a paper tiger, capable of putting huge numbers together but relatively ineffective, even incompetent, in using them.
Mandela's own position, which Keller includes in a large-type quotation, was that "nonviolence was not a moral principle but a strategy; there is no moral goodness in using an ineffective weapon".
"For me, nonviolence was not a moral principle but a strategy; there is no moral goodness in using an ineffective weapon," he explained in his autobiography.
Objectives: Aim of this study was to investigate the incidence of ineffective efforts, using continuous recordings, in critically ill patients mechanically ventilated only on assisted mode and their potential effects on patient outcome.
Many companies are ineffective in their use of social media because they still think of it as a channel for distributing a message.
Three-fifths are afraid that it will lead to a backlash against America and its allies, just under two-thirds (61percentt) predict it will lead to a longer military commitment, and a majority (51percentt) see at as ineffective in discouraging use of chemical weapons.
Methotrexate (MTX) shows consistent cytotoxicity for melanoma cells in vitro but it is ineffective in clinical use at equivalent concentrations in vivo.
Metabolism process of single strain is simple and ineffective in the use of energy substances, so that environmental adaptability is relatively weak, which results in low leaching efficiency.
However, dasatinib and other Src inhibitors have proven ineffective when used in mouse models of CRC initiation (data not shown) as well as in the clinic (Serrels et al, 2006).
