This situation suggests that standard treatment protocols are ineffective in a considerable number of cases [ 3].
Since the 400 mg dose of imatinib is ineffective in a growing number of advanced GIST patients, alternative therapy options are important in GIST treatment and disease management.
Although these drugs have shown successful downregulation of inflammation in many cases, they can immuno-compromise patients to secondary infections such as tuberculosis [ 9], or have been ineffective in a substantial number of administered patients [ 10].
As a result, health systems in a number of countries are weak and ineffective in meeting the growing need for TB control services [ 17].
Imatinib mesylate, a TKI of platelet-derived growth factor (PDGF) and c-Kit, has demonstrated an antiproliferative effect in a number of breast cancer cell lines but is ineffective as monotherapy in metastatic breast cancer (Modi et al, 2005).
In the Autumn Statement documents, the government said: "The government is publishing analysis showing that the stamp duty land tax relief for first-time buyers has been ineffective in increasing the number of first time buyers entering the market.
Follicle flushing has been shown to be ineffective in increasing the number of aspirated oocytes.
Although to date, several markers of bladder cancer have been reported, such as nuclear matrix protein 22, hyaluronic acid, hyaluronidase and nuclear matrix proteins, these markers are ineffective in reducing the number of surveillance cystoscopies due to limited sensitivity and specificity [ 6].
Workfare has been shown to be ineffective in helping those with multiple barriers to work, and ineffective in a weak labour market (2).
