In most of these cases, however, genetic engineering of entire exogenous pathways to yield those compounds does not consider the metabolic flux and balance of the organism, leading to ineffective experiments.
"Trying to cure human diseases by relying on outdated and ineffective animal experiments isn't only cruel — it's a grave disservice to people who desperately need cures".
Regardless of the bill's chances, though, we simply have to honor Barney Frank for calling for an end to the federal War On Marijuana -- the most ineffective social "war" experiment in United States history.
For site 5, although stimulation of presynaptic metabotropic glutamate receptors (mGluR1) has been shown to reduce dopamine release in mouse striatum in vitro, mGluR1 agonists were ineffective in dialysis experiments.
Indeed, low baseline levels of ACE could explain why, in our experiment, captopril was ineffective in females.
A British Medical Journal review showed how a steroid treatment was found effective in animal brain injury experiments, but was ineffective in humans and is actually associated with increased human deaths.
According to the telomere hypothesis for replicative senescence, genetic experiments using an ineffective form of human telomerase have demonstrated that telomerase inhibition can result in telomere shortening followed by growth arrest and apoptosis [ 43, 44], supporting the potential use of telomerase inhibition for cancer therapy.
In contrast, parallel treatment of mice with the IgM mAb 1E12 was ineffective, as observed in three independent experiments with different C. albicans infecting doses (Fig. 2, panel A).
These initial experiments highlighted irregular and ineffective stirring; clumps of shredded paper substrate often became trapped within the vessel leading to unstirred areas.
Since a concentration of 5 mM of either molecules was ineffective in modulating gene expression, the experiments were performed with only 10 mM of both molecules.
