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There are two mechanisms probably involved: an increase in the abdominal lymph production and an ineffective development of collateral flow.
Conventional approaches using insulin have been proven ineffective, development of new strategies to promote glucose uptake is a promising initiative.
We here review the main methodological aspects of TSPO PET imaging with particular attention to TSPO genetics, cellular heterogeneity of TSPO in brain tissue and TSPO distribution in blood and plasma that need to be considered in the quantification of PET data to avoid spurious results as well as ineffective development and use of these radiotracers.
Recently, it was found that desiccation-induced damage was caused by a dehydration-driven burst of reactive oxygen species in embryonic axes accompanied by the ineffective development of antioxidant systems (Pukacka and Ratajczak 2006; Cheng and Song 2008; Roach et al. 2008, 2010).
For example, having weak and brittle bones, having ineffective development of your cartilage, or being obese can all increase your chances of an ACL tear.
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The Global Fund's approach was conceived as a reaction against years of inefficient and often ineffective foreign development programs.
The three largest areas of savings involve Medicaid ($2 billion in annual savings), fringe benefits for state employees ($1.1 billion) and ineffective economic development programs ($800 million).
Viral isolation of LCDV is difficult, time-consuming and often ineffective; the development of a rapid and specific tool to detect and quantify LCDV is desirable for both diagnosis and pathogenic studies.
Some participants from these groups expressed that networks which have an 'alternative agenda' to the priorities of the health department resulted in 'poor' and ineffective network development because the priorities of networks were then isolated from 'the big picture'.
Two principal mechanisms may operate: on the one hand the immune systems loses the ability to detect the neoplastic population through changes in antigen presentation or editing of the antigen receptor repertoire; on the other hand initially effective immune responses may be rendered ineffective through development of an immune suppressive environment [ 2].
Chemotherapy can be rendered ineffective by the development of drug resistance.
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