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Ineffective delivery of antioxidants to the endothelium limits their utility for management of these conditions.
It may cause ineffective delivery of haemodynamic support, haemolysis, increase the risk of 'suckdown', acute pulmonary oedema or cardiac trauma.
They are rapid, aggressive and easy to apply, but their application in low permeability soils is limited due to the ineffective delivery of oxidants in such soils.
These drawbacks together with low diffusivity render the real application of stem cell therapy inefficient due to the ineffective delivery and non-specific distribution.
The primary cause of the ineffective delivery, and thus translation of nanotherapies, is the capture of the vast majority of the nanoparticles by the mononuclear phagocytic system (MPS).
Phytoconstituents like flavonoids, polyphenols possesses astonishing antitumor properties; but there is no proper utilization in terms of cancer drugs due to its solubility nature, less oral intake, and ineffective delivery.
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This new approach circumvents the problem of ineffective drug delivery and involves manipulation of TFEB.
The main outcome measure of the study was the VRS technical ES, which reflects the room for potential efficiency improvements arising from currently ineffective service delivery processes.
A paradoxical reaction in TB is defined as a clinical or radiological worsening of pre-existing tuberculous lesions or the development of new lesions in patients receiving ATT in the absence of an alternative explanation such as drug resistance, ineffective drug delivery or a secondary diagnosis [ 69].
Both IPTi and IPTc could be rendered cost-ineffective by very low transmission, mis-timed seasonal delivery, ineffective drugs, very high treatment coverage or combinations of these factors.
"Vaping active drug ingredients is an ineffective route of delivery and can be dangerous," Gottlieb said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com