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At the time, ineffective data collection made it difficult to determine exactly what was happening where.
The unrelated TAT-linked peptide was again ineffective (data not shown).
This unexpected result was specific for heparin, since a structural analog was ineffective (Data S2).
Furthermore, several independent insertions of the UAS-Gα transgenes were tested; while different Gαo transgenes all produced the folded wing phenotype upon overexpression, other Gα constructs remained ineffective (data not shown).
Lower doses of TMZ (20 μM) were completely ineffective (data not shown; n = 4).
Treatment with the inactive (R --blebbistatin (25 µM) steR --blebbistatineffective (data not shown).
Similar(52)
If it is ineffective, the data may give some indication of where and why it failed.
These results are consistent with our earlier studies showing a specific range at which DMG is active, but above or below that concentration DMG appears ineffective (unpublished data).
Recovery with citrulline was effective, whereas arginine was again ineffective (the data mimic that of arginase recovery and are therefore not shown here).
This can be attributed to a lack of capacity and funding, ineffective coordination, poor data management and limited data access, and the lack of any assessment of EWS.
Data on the management of patients with advanced SFT is scarce: chemotherapy has been described as ineffective, while recent data suggests that anti-angiogenic therapies may be more efficient.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com