Ineffective control of Th17 immune responses is a potential mechanism to explain why IL-4R is an important severity gene in RA, but this issue will require careful study of a cohort of new-onset RA patients.
These results have important implications for explaining the ineffective control of PSTVd in China and thus could serve as a basic reference for designing more effective measures to eliminate PSTVd from China in the future.
Such delayed crisis planning often leads to hurried and flawed designs, wasteful spending and ineffective control of invaders.
At the same time, the rural and urban poor in both cases experience higher rates of both traditional communicable and infectious diseases (many of which are related to poor sanitary conditions, unhealthy housing, and ineffective control of vectors) and modern diseases, which are exacerbated by limited access to health care and failed health care policies.
Although we did not evaluate CD57 expression in this study, if the increase in CD28- T cells in Malawians was associated with increased CD57 expression, reduced functional capacity and poor proliferation in response to antigen, this might lead to ineffective control of infections.
Sanitary measures adequate for eliminating bacteria and parasites seem to be ineffective in control of rotavirus, as the incidence of rotavirus infection in countries with high and low health standards is similar.
His department has been accused of having weak management, ineffective control and poor governance; a fortress mentality, a "good news" reporting culture, a lack of transparency, inadequate financial control, and ineffective oversight.
The lack of adjustment for these artefacts might well render ineffective the current strategies for the control of the disease.
Our current inability to quickly detect arboviral infections in endemic communities has led to inaccurate risk assessments, underdiagnosis of clinical cases, and ineffective control measures.
Amyas Morse, the head of the National Audit Office, said the "relatively high risk trajectory" was met by "weak management, ineffective control and poor governance".
