Sentence examples for inductive site from inspiring English sources

Desvignes, C., Esteves, F., Etchart, N., Bella, C., Czerkinsky, C. & Kaiserlian, D. The murine buccal mucosa is an inductive site for priming class I-restricted CD8+ effector T cells in vivo.

Consistent with this, they have the architecture required of a classic inductive site (B-cell follicles, immunoglobulin class switching and the presence of naïve and memory T-cells).

A fusion construct (Tet-EDIII-Co1) consisting of an M cell-specific peptide ligand (Co1) at the C-terminus of a recombinant tetravalent gene encoding the amino acid sequences of dengue envelope domain III (Tet-EDIII) from four serotypes was expressed and tested for binding activity to the mucosal immune inductive site M cells for the development of an oral vaccine.

Upon encounter with foreign antigens, DCs migrate from mucosa to the nearest inductive site where they act as APCs [6].

Mucosal immune surfaces are interconnected and stimulation of the inductive site in one mucosal surface, produces an immune response at distant mucosal surfaces [11].

However, a more recent analysis has suggested that the rabbit vaginal vault may be an immune inductive site when very high doses of antigen are applied on a frequent basis [44].

Of note, IL-10-producing CD4+ T cells exert regulatory functions, thereby suggesting that IEC PPAR γ is required for the induction of T cell regulatory responses at the mucosal inductive sites and the prevention of experimental IBD.

However, there is considerably disparity with regard to migration of memory/effector cells from mucosal inductive sites to secretory effector sites and systemic immune organs.

The data suggest that antigen-presentation capacity is maintained in inductive sites of SIV-infected rectal mucosa, but immune effector functions may be altered.

This versatile system permits expression of incorporated antigens in either surface-bound or secreted forms by the ZCR533 vector, for delivery to the mucosal inductive sites.

These carrier vaccines are engineered to deliver sufficient levels of protective antigens to appropriate lymphoid inductive sites to elicit both carrier-specific and foreign antigen-specific immunity.