Exact(32)
Membranes (mostly EC) with dispersed metal powder were cast in an external magnetic field of a specially designed coil (magnetic induction up to 0.04 T).
In the CYP-linked enzyme assays, a significant induction (up to a 57-fold increase in the deethylation of ethoxyresorufin with PAA treatment) and a notable inactivation (up to almost a 90% loss in hydroxylation of p-nitrophenol with all disinfectants, and of testosterone 2β-hydroxylation with NaClO) was observed in subcellular liver preparations from exposed fish.
This revealed a mild, but significant, mefloquine driven gene induction up to 1.5 fold.
Highest induction (up to 9-fold) was found in IL-6-treated cells between 24 and 36 h.
A third large group of genes displayed transient induction (up at 4 h only) in all treatments, but less so with HRG in the HB4a cells (red band).
Strong induction (up to 160-fold) was seen in a suite of proteins involved in exocytosis (exoc2, rab3ab, exoc8, arf6 and iqgap2).
Similar(28)
Using MDA-MB-231 cells, in which FOXO3a activity can be induced by 4-hydroxytamoxifen, we showed that FOXO3a induction up-regulates PI3K-Akt activity and enhanced doxorubicin resistance.
E2F1 induction up-regulated target genes involved in G1/S transition through E2F sites.
Diabetes induction up-regulated the PEPCK gene expression by 2.88 and 1.83 folds in the liver and muscle tissues respectively, but suppressed it by 3.08 in the adipose relative to the non- diabetic rats (P <0.05).
In comparison with NSP4, the productivity of secreted ATH35L for dsbAss increased from 0.12 g/L at 8 h post-induction up to 0.2 g/L at 12 h post-induction.
Notably, either repression was good, i.e. less than 10% of the cells were Venus+ then re-induction was also poor (20 30%), or the system was leaky (>20% Venus+ cells) allowing high levels of re-induction (up to 80%, e.g. in CD8+ T-cells).
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