Because p21 is obviously essential for cell cycle arrest induction after radiation [ 62, 66] and radiation increased the expression of p21 [ 66], a key role of p21 in radiation-induced cell cycle arrest in the cellular response to DNA damage [ 67] has been suggested.
As in vitro and in vivo studies have also demonstrated HIF-1α induction by radiation [ 20, 32], we speculate that radiation induced PAI-1 up-regulation might occur via HIF-1α.
The numerical algorithm incorporates the calculations of radio-frequency, time-harmonic magnetic field by induction heating, radiation and conduction heat transfer in the system, as well as the growth kinetics.
For the p21CIP1 induction by radiation 50,000 cells were seeded per 6-well.
The mechanism of cancer induction by radiation suggested in our study is not clear.
The child's thyroid is one of the most sensitive human tissues to cancer induction by radiation.
We have also been able to compare nuclear fluorescence attributable to specific PE staining with total cellular fluorescence and thus compare fluorescence induction following radiation exposure utilizing imaging flow cytometry (nuclear fluorescence) with zero resolution flow cytometry (total cellular fluorescence).
Adjusted for the interactions of tumor histology and tumor location with surgery, age, Karnofsky performance scores, tumor histology, induction chemotherapy, radiation modality and surgery for non-EC specific death free survival.
Other factors analyzed in univariate analysis include: age, sex, race, BMI, heavy alcohol use history, smoking at diagnosis, second malignancy, Karnofsky performance scores, tumor histology, tumor location, tumor differentiation, clinical stage, induction chemotherapy, radiation modality and their interactions with surgery.
Furthermore, p27 haploinsufficient mice are more sensitive to malignant tumor induction by radiation and chemical carcinogens [ 2], and allelic haploinsufficiency for p27 is found in some human tumors [ 3, 4, 5].
