Sentence examples for induction pathology from inspiring English sources

Thus, it is possible that in the experimental studies using PFSPs the natural barriers to induction and spread of αS induction pathology were artificially overwhelmed beyond concentrations that would normally occur.

Although studies using cerebral injection of PFSPs or brain extracts are suggestive of induction and spread of αS induction pathology by protein conformational templating, there are many important issues to consider that make it likely the experimental procedures potentiate this process and that several other mechanisms are involved (Fig.  3).

This paucity of CNS αS induction pathology in WT mice following the peripheral exposure to PFSPs is consistent with the normally low level of expression of endogenous αS in the peripheral nerve and the spinal cord in WT mice [ 63, 161].

Alternatively, these studies do strongly suggest that other mechanism(s) of induction of pathology by exogenous αS should be considered.

To definitely demonstrate that the induction of pathology was specifically due to transmission of αS molecules, a key experimental control usually includes αS immuno-depletion where the αS present in the sample is removed by antibody absorption.

In both the Masuda-Suzukake et al. [ 21] and Luk et al. [ 20] studies using nTg mice, soluble αS was injected as controls and no induction of pathology was reported.

Other studies suggest the plausible role of ultrafine particles found in air pollution in neuroinflammation and in the induction of pathology associated with Alzheimer's disease (Calderón-Garcidueñas et al. 2002, 2004).

Besides cancer, other diseases could also benefit from antibody-directed therapies, the only prerequisite being the identification of a receptor exclusively expressed on those immune cells involved in the induction of pathology.

The later conclusion has been strongly supported by the elegant immuno-depletion experiments performed by Jucker and colleagues [ 23] and the induction of pathology by synthetic Aβ aggregates [ 35].

Several investigators have suggested that SAF may play a role in the induction of pathologies, particularly cancer, and do not recommend immediately ruling out this particle size class [ 19- 22].

However, this mechanism of pathology induction remains to be formally proven in vivo, as other possible mechanisms could contribute to αS inclusion pathology induction including disruption of proteostasis and innate immune activation [ 22- 25].