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Material-conditioned media studies found Medeor Matrix to have the greatest positive effect upon cell proliferation and induction of migration.
Our data indicate that, similar to its role in controlling tissue architecture during development, BMP signalling regulates regeneration of the airways following acute injury, involving downregulation of E-cadherin and induction of migration in AECs.
Previous work documents its ability to directly influence proliferation, differentiation, and maturation of myeloid progenitors along with induction of migration, survival and activation of mature hematopoietic cells[42] [44].
Among the many cytokines, chemokines, and other effectors associated with wound repair, hCAP-18 stands out as candidate with multiple effects on monocytes including the induction of migration [12], [13] and differentiation of monocytes to dendritic cells (DCs) [14].
Induction of migration.
Remarkably, cells treated with U0126 significantly blocked ERK1/2 activation and the induction of migration and invasion by syntenin overexpression.
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It is also possible that the circadian clock is involved in the induction of butterfly migration, as migration is initiated in the fall, in part, by decreasing daylength [26].
Medium that was prepared in parallel in the absence of monocytes did not exert any significant effect on VSMC migration (see Supplementary material online, Figure S5 ), indicating that the observed induction of VSMC migration is due to monocyte-derived products and not due to the residual presence of A23187 and/or AA in the prepared medium.
Alternagin-C exerts a variety of activities, including the induction of neutrophil migration via integrin signaling [ 41], stimulation of human umbilical vein endothelial cell migration [ 43, 46] and modulation of angiogenesis in vitro and in vivo [ 47], but has a limited beneficial effect on muscle regeneration [ 48].
The aim of the present study was to investigate the effect of static strain on bone marrow mesenchymal stem cell (BMMSC) migration and whether the p38/matrix metalloproteinase-2 (MMP-2) axis plays a role in induction of BMMSC migration under mechanical strain.
Adjusting model parameters to recapitulate epithelial scattering reveals that induction of cell migration is the major driver of epithelial scattering.
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