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Among them, DB-51630, which showed approximately 350 times higher preferential binding to GC-repeats than to the AT and AA-repeating oligomers, caused the induction of a specific mRNA.
This leads to "endothelial dysfunction" with a reduction in endothelium-dependent vasodilation and the induction of a specific state of "endothelial activation," characterized by a proinflammatory, proliferative, and procoagulatory milieu which favors all stages of atherogenesis, pathological inflammatory processes, and vascular disease [14].
We demonstrate that induction of a specific subset of cytokines is dependent upon integrin α3β1-mediated endocytosis of the ligand.
Nevertheless, perception of plant root tissue by the pathogen occurred, leading to the induction of a specific subset of genes.
These numbers indicate a general downregulation of the entire transcriptome, combined with a focused induction of a specific set of damage response genes, lexA dependent and others.
Here, we show that the natural retinoid, atRA, and several synthetic retinoids elicit rapid and robust induction of a specific isoform of AKAP12 (AKAP12β) in vascular SMC.
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This mechanism would circumvent the need for de novo synthesis of Ad structural proteins for induction or recall of Ad-specific CD8+ T cells [33].
In induction, synthesis of a specific enzyme, called an inducible enzyme (e.g., β-galactosidase in Escherichia coli), occurs when cells are exposed to the substance (substrate) upon which the enzyme acts to form a product.
Here we present a detailed protocol for the induction of a regionally specific NC intermediate that occurs over the course of a 15-d interval and is an effective source for the in vitro derivation of functional enteric neurons (ENs) from hPSCs.
These studies provide a rational model for the design and assessment of new minimal-epitope vaccines based on their in vivo induction of a pathogen-specific CTL response.
Furthermore, we previously showed that PC growth is accompanied by the progressive induction of a Tag-specific CTL tolerance that reaches a full state at around 11 weeks of age [29], [30].
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