Furthermore, in the absence of IFNγ induction, no disruption of the T. gondii vacuole was detected, suggesting that a high level of expression of Irga6 alone is not sufficient to complete the resistance mechanism.
However, the cancer cell lines treated with cytochalasin D showed no changes in cell morphology or Wnt5a induction, suggesting disruption of this regulatory pathway in cancer.
Given the general observation of OGlcNAcylation and phosphorylation in transcriptional regulatory elements and the broad importance of α-helical recognition epitopes in transcription, these data suggest the possibility of direct structural effects of both post-translational modifications on transcription, via both induction and disruption of recognition α-helices.
We have demonstrated in thyroid oncocytoma, which constitute a model of mitochondrial-rich tumours, a high rate of PRC induction, with no disruption of mitochondrial functions [15].
However, there is little information as to the mechanisms underlying the induction of microtubule disruption by organosulfur compounds.
However, the long-term effects of low concentrations of nonylphenol on vitellogenin induction and gonadal disruption in roach are unknown.
Unresolved ER stress is typically marked by persistent UPR induction and subsequent disruption of ER architecture and function.
Taken together, we conclude that p53 induction upon Rps27l disruption is unlikely due to aberrant protein synthesis, but reduced rRNA processing may contribute to some extent.
The availability of cloned/expressed human enzymes and specific antibodies has enabled the investigation of xenobiotic induction and metabolic disruption leeding to adverse responses.
Based upon this quantified measure, we have modified our conclusion by stating now that "p53 induction upon Rps27l disruption is unlikely due to aberrant protein synthesis, but reduced rRNA processing may contribute to some extent".
