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Caspases are proteolytic enzymes mainly involved in the induction and execution phases of apoptosis.
Here we hypothesize that oncolytic immunotherapy replication within tumors may tip the immune balance to allow for the effective induction and execution of adaptive anti-tumor immunity, resulting in long-term tumor control following OI clearance.
Although different apoptotic pathways have been described, major players in induction and execution are caspases.
These findings suggest that disturbances in autophagosome turnover can further inhibit proper induction and execution of autophagy, potentially worsening the cellular capacity to degrade APP and its metabolites.
Destruction of Ssn8 is required for induction and execution of meiotic development; deletion of SSN8 results in unscheduled meiotic gene expression [19].
Hence ATP availability is central in the induction and execution of necrosis.
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Recently, the prominent role of ROS has been revealed in the induction, signalling and execution of plant cell death (Jabs [1999]; Apel and Hirt [2004]; Karuppanapandian et al. [2011]).
In plants ROS have prominent roles in the induction, signaling, and execution of PCD [ 58].
The reactive oxygen species (ROS) contribute to the induction, signalling and execution of plant cell death [ 16- 18].
In plants, the prominent role of reactive oxygen species (ROS) has been revealed in induction, signaling, and execution of programmed cell death (PCD) [ 47].
There is ample evidence demonstrating the active involvement of reactive oxygen species (ROS), and H2O2 in particular, in the induction, signaling and execution of blast resistance in rice [ 48- 51].
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