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Oxytocin is a potent uterotonic agent that is widely used for induction and augmentation of labor.
This risk has been partially alleviated by the use of the Institute of Healthcare Improvement's bundle methodology for safe initiation of oxytocin for labor induction and augmentation.
‡Percentages may not add up to 100% if women had induction and augmentation.
In addition, its role as a mediator in fever induction and augmentation of pain is well established [ 9].
Risk factors for severe perineal lacerations include increasing birth weight, operative vaginal deliveries, labor induction and augmentation [ 8].
65 We found no association with induction and augmentation, agreeing with an earlier report 73 but at variance with others.
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The increasingly medical approach to birth in the Netherlands is demonstrated by growing demand for medical pain relief, increasing use of inductions and augmentation in labour, and a related decreasing number of births in primary care [ 6, 7].
The addition of the obstetric factors such as labour induction and labour augmentation, followed by epidural analgesia and caesarean delivery, made little difference to the odds ratio for the temporal increase in PPH with blood transfusion (Table S4).
We further carried out sensitivity analyses in which covariates were added incrementally to the model, starting with maternal pre-pregnancy factors, followed by maternal pregnancy factors, and lastly obstetric factors, namely, labour induction and labour augmentation, epidural analgesia, and mode of delivery.
Besides previously examined risk/protective factors for atonic PPH, we also controlled for pre-pregnancy BMI and other factors such as labour induction and oxytocin augmentation, but were unable to explain the temporal increase in atonic PPH and severe atonic PPH.
We calculated the sample size for the MidU trial using estimates for induction of labour, episiotomy and augmentation of labour.
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