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The largest of these probably equates to bovine MMP-9 (both pro- and active); there was an induction and activation of MMP-2 and an induction of a lower-molecular-weight activity that may represent collagenases MMP-1 and MMP-13, but could include other MMPs, many of which have at least some activity against gelatin.
Another mechanism sustaining the effect of 5-ASA is the induction and activation of peroxisome proliferator-activated receptor-γ (PPARγ) (14).
p62 induced this ROS production by a DLK1-dependent induction and activation of the small Rho-GTPase RAC1, activating NADPH oxidase and being overexpressed in human HCC.
This is why a network of positive and negative feedback loops, which most likely evolved to fine-tune the activity of this tumor suppressor, modulate its induction and activation.
It thus seemed that atrazine may generate signals that activate some H2O2-producing pathways, and that impair the induction and activation of antioxidant defence mechanisms.
It is proposed that induction and activation of UCP2 may play a role in the thermogenesis evoked by hepatothermic therapy, a strategy designed to decrease body fat by maximizing hepatic fatty acid oxidation.
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Skin-accumulating CQ disrupts bite-site antigen presentation leading to Treg-induction and activation.
Pro-inflammatory conditions counteract [100], [262], and inhibit [227], [263] DC tolerization and directly disrupt Treg-induction and activation in mucosal skin [264], and can convert Tregs to effectors [265].
HBx also sensitizes hepatocytes to p53 apoptosis via activation of the p38MAPK pathway, which couples p53 stabilization and p53 activation, by E2F1 induction and ATR activation, respectively [ 189].
There has been extensive interest in the role that platelet activation can have in the inflammatory response through induction, aggregation and activation of leucocytes and other platelets.
TLR4 induction, signaling, and activation in numerous cancers such as breast cancer, colon cancer, ovarian, and prostate cancer were also identified [ 56].
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