Sentence examples for inducing replication from inspiring English sources

Oncogenes can cause genome instability by inducing replication stress, but the molecular mechanisms that underpin this process were unknown.

The Nsp2-targeted siRNA was found to downregulate the expression of Nsp2 in MARC-145 cells and inducing replication reduce of PRRSV in MARC-145 cells.

These agents along with the laboratory workhorse for inducing replication stress, HU, are strong activators of the ATR pathway.

It is possible, therefore, that hyperglycemia and other factors can initiate tumorigenesis by inducing replication stress that leads to mutational activation of oncogenes.

ATR is activated by a wide spectrum of DNA damages inducing replication stress while ATM is activated primarily by DNA DSBs [ 9, 42, 43].

Thus, as in budding yeast, growth signaling may impact aging in more complex organisms, including humans, by inducing replication stress, in addition to oxidative stress.

Of note, endogenous expression of telomerase in murine HSCs was sufficient to alleviate aneuploidy-induced replication stress at telomeres and aneuploidy-induced senescence.

Jones, R. et al. Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.

Clynes, D. et al. ATRX dysfunction induces replication defects in primary mouse cells.

McEachern, M.J. & Haber, J.E. Break-induced replication and recombinational telomere elongation in yeast.

Tsantoulis, P. K. et al. Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions.