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It is likely that the essentiality of these genes is attributable to common metabolic requirements among ccRCC cell lines (e.g., a high lactate secretion to glucose uptake ratio or secretion of secondary metabolites), which induces dependence on the expression of enzymes that activate the related metabolic pathways.
Finite population history induces dependence between allelic states, both within and between individuals.
If common parameters are used across time periods then the use of some individuals as controls within multiple time periods induces dependence between contributions to the likelihood and robust variance estimates should be used.
Setting r ^ = 1 resulted in lower levels of statistical significance, and there was no obvious evidence of adverse effects from the fact that ignoring the 2nd PC induces dependence in the residuals of the model used with r ^ = 1 (Leek and Storey, 2007, 2008).
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Although the mechanism of staurosporine actions is not well understood, stauroporine has been shown to partially function through caspase-dependent mechanisms, which is a prerequisite initiation step for inducing dependence receptor cleavage in the absence of ligand binding.
Two days later, they were implanted with morphine or placebo pellets (to induce dependence in morphine-pelleted animals) for 2 weeks, followed by forced abstinence.
Through the modulation of γ-aminobutyric acid and glutamate release by the cannabinoid type 1 receptor, cannabinoids can activate the dopaminergic mesolimbic system and induce dependence in regular or heavy marijuana users.
It is also worth noting that the rotations will be considered as independent, when in fact there may be spatially induced dependence.
Nonbenzodiazepines are contraindicated during benzodiazepine withdrawal as they are cross tolerant with benzodiazepines and can induce dependence.
The majority of patients respond well but the long-term treatment may induce dependence on the exogenic heme.
However, it is unclear whether loss of ephrinB3 alone is sufficient to induce dependence receptor-mediated cell death.
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