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We previously reported that the expression of a rice AP gene (OsAP77, Os10g0537800) was induced by probenazole (PBZ), a chemical inducer of disease resistance.
Aminobutyric acid derivative, such as β-aminobutyric acid (BABA), an inducer of disease resistance in plants possesses a large spectrum of activity in inducing resistance against disease in peas, potato, tomato, tobacco, apple, grapevine, cucumber, and other plants [7, 8].
We postulated that this gene might be involved in the defense response against pathogens because PBZ is a chemical inducer of disease resistance (Watanabe et al. [1977]).
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While some bacteria are inducers of disease, others, known as probiotics, are able to reduce inflammation.
CMap can thus be used as an unbiased in silico screening approach to identify drugs that have either positive or negative connectivity scores, implicating these drugs either as potential inducers of disease phenotypes or therapeutics thereof.
In general, the action of viruses and mobile genetic elements is important in host evolution [ 16, 42- 47] because they are vectors of evolution and potential inducers of diseases and genetic disorders, such as chromosome rearrangements and inversions [ 48].
Probenazole (PBZ) is a well-known chemical inducer of plant disease resistance (Watanabe et al. [1977]) and has been used to protect rice from blast disease for more than three decades in Japan.
These results coincide with reports indicating that a single serotype [ 24] or a single clone [ 25, 26] is the inducer of oedema disease at herd level.
Whether microglia activation is a secondary event following the ongoing neurodegeneration or a primary inducer of the disease remains to be defined.
Several strains of E. coli have been discussed as inducers of oedema disease, but from a historical point of view the disease have been associated to principally four strains of E. coli belonging to three different serotypes: O138 K81, O139 K12, O141 K85a,b:H4 and O141 K85a,c H4 [ 22, 23].
Cadmium toxicity has long been appreciated as an inducer of various cardiovascular diseases.
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