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Thus, the 92% replacement of the inducer by a non-inducing sugar preserved at least 50% of the specific productivity.
If substrate is present, it acts as an inducer by combining with the repressor so as to prevent its binding to DNA.
Copper has been reported to be a strong laccase inducer by many researchers.
Nuclear receptor Nur77 could induce the conformation change of Bcl-2 protein and converted it into an apoptosis inducer by "enemy to friend" strategy.
The second factor included 4 levels of drought stress inducer by applying 0, 5, 10 and 20% of polyethylene glycol-6000 (PEG) which is equivalent to four osmotic potential levels including −0.001, −0.27, −0.54 and −1.09 MPa, respectively.
In support of this idea, recently the sugar laminaribiose was identified as an inducer (by inhibiting binding of the negative regulator GlyR3) of the celC gene cluster encoding non-cellulosomal enzymes in C. thermocellum [39].
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ZEB1 and ZEB2 typically act as EMT inducers by suppressing E-cadherin expression, however in the presence of miR-200, ZEB1 and ZEB2 could not interact with E-cadherin and the epithelial phenotype was maintained [45],[45].
The current rapid expansion of biological knowledge offers a great opportunity to rationally engineer biological systems that respond to signals such as light and chemical inducers by producing specific proteins.
As previously shown, MGO constitutes a potent stress-inducer by impairing UPS activity, leading to the accumulation of damaged and modified proteins in the cell.
To solve this absence of antigenicity and immunogenicity, hundreds of trials were carried out with native and modified HABPs in large numbers of Aotus monkeys, finding that conserved HABPs could be rendered immunogenic and sterilizing immunity inducers by replacing their critical host cell binding residues by others having similar mass but opposite polarity.
Hence, our model indicated that p53-deficient cells might be sensitized to SSBs inducers by inhibition of Chk1.
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