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Journal of Toxicology, Special Issue "Metals and Disease" 2012 132671.Epub 2012 Jan 12. Florea AM and Büsselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects.
The rate of severe radiation induced side effects was very low.
Electron microscopy is essential to look for chemically induced side effects at the cellular level.
Moreover, the use of ancillary drugs to treat or prevent steroid induced side effects was seen as an important aspect of 'responsible' steroid usage.
The use of a two choice design helped avoid confounding factors induced by drug induced side effects.
However, colonic fermentation induced side effects, such as excess gas production, remain an issue for these compounds.
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Drug interactions were also shown either to suppress Hsp72 protective effects exacerbating therefore drug-induced side effects or to induce Hsp72 beneficial effects by suppressing drug-induced exacerbations.
Prevention, identification, and effective management of medication-induced side effects are important to maximize adherence and reduce health resource use in schizophrenia.
Specific immunotherapy using recombinant allergens is clinically effective; still wild-type allergens can provoke treatment-induced side effects and often show poor immunogenicity in vivo.
The new approach also holds great potential for improving drugs' effectiveness, identifying better combination therapies, and avoiding dangerous drug-induced side effects.
DeMAND addresses several key challenges to drug development, holding great potential for improving drugs' effectiveness, identifying better combination therapies, and avoiding dangerous drug-induced side effects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com