These measures were felt to be sufficiently containing to prevent experimentally induced relapse.
This requires 4 of 8 symptoms including exercise induced relapse, myalgia, arthralgia, headache of a new and different type, nonrestorative sleep, cognitive complaints, sore throat and tender lymph nodes.
In pre-clinical models, anti-vascular endothelial growth factor (anti-VEGF) drugs (sunitinib and anti-VEGFR2 blocking antibodies) were shown to inhibit localized tumor formation, but potently induced relapse and metastasis [ 90- 92].
TLR 7 which is a sensor for viral single-stranded RNA and is believed to play an important role in viral hepatitis infection was upregulated 2.48-, 2.44-, and 3.26-fold more than the control values in IFN induced, relapsed, and cirrhosis patients, respectively.
Some leukemias have been tied to cancer "stem cells" that may drive the early stages of illness and possibly induce relapses.
Injection of mAbs against these epitopes induces relapses in chronic arthritic mice.
It is also possible to induce relapses with single mAbs in the mice that had previously developed chronic CIA [ 44], demonstrating the role of antibodies in relapses during the chronic phase of arthritis.
H L ratio is also strongly positively correlated with corticosterone levels [ 50], but increases with increasing environmental stress, so these data do not support the idea that increased corticosterone, induced by food stress or poor weather, induces relapses of active parasite infection [ 36].
In human participants, reintroduction to an environment previously associated with drug-taking may induce relapse.
In conclusion, there appears to be a good correspondence between the events that induce relapse and loss of control over alcohol-taking behaviour in laboratory animals and those that provoke relapse and loss of control in humans.
