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ALVAC-HIV (vCP205) induced low levels of neutralizing antibodies against HIV-1 MN in 33% of the volunteers.
The drug strongly inhibited DNA synthesis and induced low levels of apoptosis at clinically relevant concentrations in a subset of three of the lines (L3.6pl, BxPC3, and Cfpac1).
Arabidopsis thaliana inoculated with the endophytic Streptomyces sp. strain EN27 induced low levels of gene expression related to the JA and ET pathways [93].
Priming immunization with IIIB rgp120 HIV-1 vaccine alone induced low levels of antibody capable of binding to envelope glycoprotein of primary isolate strains of HIV-1, and booster immunizations with MN rgp120 HIV-1 vaccine resulted in much higher antibody levels.
CD134-Fc only induced low levels of MCP-1 and no IL-10 (Figure 4C).
Additionally, NOR CD4hi T cells induced low levels of pro-apoptotic Bcl-XS in response to Fas engagement (Figure 5B).
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As expected, results show that TNFα alone and fMLP alone, induced low level of ROS production, and punicic acid had only a moderate inhibitory effect on this process (Figure 4A, 4B and 4C).
Fernandes et al. (47) conducted site-specific mutagenesis studies and observed that in the 5′-CpG-3′ duplex of interest in this work, only stereoisomers 2 and 3 of the HNE-induced exocyclic 1, N-dG adduct were mutagenic, inducing low levels of G → T transversions and G → A transitions(47).
Compared to the wild-type S. typhimurium strain I77 in both SIV-infected and SIV-uninfected nonhuman primate hosts, this live-attenuated vaccine shows reduced shedding and systemic spread, exhibits limited pathological disease manifestations in the digestive tract, and induces low levels of cellular infiltration in tissues.
Activation of adult blood through TLR9 induces low levels of inflammatory cytokines such as IL-6 and IL-8.
LPS by itself is capable of inducing low levels of IL-1β secretion, but IL-1β secretion increased significantly when DC cells were treated with LPS plus the ionophore nigericin (Nig), which activates the Nalp3 inflammasome by inducing K+ efflux.
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