Exact(1)
Your operating theory can be that fear loves a group, because it's contagious, or it can be that fear is best induced in isolation, one victim at a time.
Similar(59)
Cholesterol accumulation was induced in BHK cells to allow isolation of late endosomes by subcellular fractionation.
Though Mayr (1942) is largely remembered for elaborating the concept of allopatric speciation (see Thanukos 2008, for a review), in reality, it was Dobzhansky who had first resurrected the importance of isolation (primarily geographically induced) in speciation and thus to the evolutionary process in general.
In brief, spontaneous apoptosis was induced in xenograft ALL cells directly after isolation from leukemia-bearing recipients by culture for 16 h (RPMI 1640 medium, supplemented with 10% fetal calf serum, penicillin, streptomycin and glutamine at 37 °C in humidified air with 5% carbon dioxide).
Regarding LTD susceptibility as a function of the delay after slice isolation, no noticeable depression was induced in either group of animals for slices analyzed 1 to 3 h after the isolation procedure (Figure 4B).
To explore the ability of E-cadherin loss to induce an EMT in isolation of other genetic changes, we mined the relative expression of well characterized EMT genes and their transcriptional regulators in MCF10A and MCF10A CDH1-/ cells.
Although this possibility remains to be definitively demonstrated, it is thus conceivable that similar changes in basal [Ca2+]i induced by slice isolation occur in hippocampal neurons, accounting for the time-dependence of LTD induction as well as for the weaker initial LTD in aged rats that is not observed at longer periods of slice recovery.
Neonatal rats were isolated daily for 1 h from postnatal day (P) 4 to 9, a manipulation previously shown to induce hypothalamic pituitary adrenal (HPA) responses on P9 (Knuth, E.D., Etgen, A.M. (2005) Corticosterone secretion induced by chronic isolation in neonatal rats is sexually dimorphic and accompanied by elevated ACTH.
In this work, detailed fragmentation pathways were elucidated by further dissociation of each fragment ion in the ion spectrum, essentially, by incorporating fragmentor voltage induced dissociation (in-source fragmentation) and isolation of fragments in a quadrupole cell Q1.
As such, our results provide novel insights into the marked magnitude of alterations induced by mitochondrial isolation methods in every aspect we examined (structure, function, electron transport chain stoichiometry).
Thus, although further analyses are needed to clarify the mechanism, the results suggest that ATF-7 may play a critical role in epigenome change induced by social isolation stress.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com