Farrowing was induced at gestation day (GD) 114 as described previously [ 15].
To identify potential Ets1-driven alterations in skin epithelium, we examined E18.5 embryos in which Ets1 was induced throughout gestation.
In cattle, osteopetrosis can either be induced during gestation by viral infection of the dam, or inherited as a recessive defect.
Outcomes included maternal blood pressure at <20 and ≥20 weeks <span class="lh">gestation and pregnancy induced hypertensive diseases (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome).
Induced abortion and miscarriage rates were defined as expulsion of dead fetuses at less than 7 months of gestation induced by any means or without inducement, respectively, per 1000 pregnancies that had an outcome.
Experiments with prenatal protein restriction indicate that the insult can induce hypertension at any stage of pregnancy [16], [42], but that effects are greatest if the undernutition is induced later in gestation.
TCDD, administered during gestation, induced the postnatal activities of p-nitrophenol glucuronyltransferase and benzpyrene hydroxylase in rats.
In an animal model, IUGR induced in late gestation produced alterations in alveolar function, corresponding to rapid development of alveoli during this time period (Maritz et al. 2001).
We have previously observed that a similar nutritional challenge imposed earlier in gestation induced long-term programming effects on hypothalamic gene expression (10).
Genes induced with advancing gestation included those that were functionally enriched in various signaling transduction pathways (NGF, RAS, MAPK, VEGF, EGFR1 signaling), lipid and surfactant homeostasis, mediated cell immune response and response to growth factors (Figs. 2b and 3a).
We show that maternal injections of LPS at mid late gestation induced an increase in cytokines in the foetal brain as well as changes in neural cell maturation and patterning.
