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Chauhan et al. (2003) found that participants exposed to high levels of NO2 in the week before the onset of polymerase-chain-reaction confirmed virally induced exacerbation had worse symptom scores and lower PF than did participants exposed to low levels of NO2 before their virally induced exacerbations.
For example, children with gene variants in STAT4, JAK2, MX1, VDR, DDX58, EIF2AK2 [48], and cadherin-related family member 3 (CDHR3) [49] showed a higher incidence of viral induced exacerbations.
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Drug induced exacerbation of seizures are difficult to detect clinically because of the natural history of epilepsy, with periods of seizure exacerbations unrelated to a particular drug regimen.
Comprehensive investigation of epigenetic mechanisms prior to, during and after virus induced exacerbation could therefore reveal if component(s) of the epigenome contribute to the development of exacerbation.
This observation is noteworthy since vaccine induced exacerbation of BRSV infections has been reported from field observations [ 24] and reproduced in the laboratory [ 25].
Rhinoviruses (RVs) are a major cause of common colds and induce exacerbations of asthma and chronic inflammatory lung diseases.
Although ozone induces exacerbations of asthma and COPD, and has also been implicated in accelerating cardiovascular disease, the precise cellular and molecular mechanisms are poorly described.
The process of switching drugs or adjusting dosage may induce exacerbation of the illness and subsequent recurrence.
This paradigm could explain why in monkeys that have recovered from CIA it is almost impossible to induce exacerbation of the arthritis by a second immunization with bovine collagen type II [ 26, 51].
Hence, lactate dehydrogenase (LDH), an indicator of cell lysis, is a sputum marker of RV-induced exacerbations 4. Mechanisms involved in RV-induced asthma exacerbations and in the development of severe asthma remain to be defined in several respects, and novel treatments are needed for these severe conditions.
For this purpose, we designed an allergen-driven rechallenge model of allergic airway inflammation in mice, to assess the effectiveness of tiotropium and the long-acting β-2 adrenoceptor agonist olodaterol on allergen-induced exacerbations of airway disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com