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Yart et al. [14] reported that siRNA-mediated knockdown of parafibromin and hPaf1 on ansynchronously growing HeLa and U2-OS cell populations induced entry into S phase, validating our data.
Indeed, when LMP2A was transiently transfected into non-anergic EBV-positive B cells, it induced entry into the EBV lytic cycle, which is associated with production of BZLF1 and Virus Capsid Antigen [ 28].
In addition, Schmitt et al. found that upregulation of miR-145 repressed junctional adhesion molecule-A (JAM-A) induced entry of monocytes into the sites of atherosclerotic lesions, suggesting that miR-145 may inhibit atherosclerotic formation via downregulation of JAM-A in endothelial cells [ 48].
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Favoring the allocation to entrants is a way to induce entry and thus create competition.
Prolonged ex vivo manipulation induces entry into the cell cycle resulting in proliferation.
In addition to inducing entry into the cell cycle, cyclin D1 may also act in a negative feedback manner to repress STAT3 activity by reducing nuclear p-STAT3 [56].
Some of the known conditions that induce entry into the VBNC state are cold, starvation, chlorination, and osmotic stress [12], [13].
Indeed, HPV-16 expressionion can a) accelerate or induce entry into the cell cycle [8], [9], b) induce mitotic abnormalities hence increasing genomic instability [36], [37], and c) increase cell survival, at least via the pro-survival mechanisms discussed above.
In contrast, virus-transduced HepG2 and 293 cells contained high amounts (49-fold and 10-fold more, respectively) of internalized E. coli particles (P<0.001), indicating that virus could induce entry of bacteria in non-phagocytic human cells.
By providing a BCR-like signal, LMP2A induces entry into the viral replicative cycle [55], [56].
KinA overexpression during exponential growth is sufficient to induce entry into sporulation [ 20].
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Justyna Jupowicz-Kozak
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