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We induced delayed retrograde degeneration of the nigrostriatal system in rats by injecting 6-hydroxydopamine (6-OHDA) intrastriatally.
The cytokine pattern in a normal, undisturbed healing differs from one in a mechanically induced delayed healing.
The cytokine expression and also the cellular composition in all compartments was significantly altered under mechanically induced delayed healing conditions.
Cilostazol induced delayed migraine-like attacks in 12 patients (out of 14) compared to 2 (out of 14) patients after placebo (P=0.002).
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in headache research.
Ethanol induced delayed trigeminal hypersensitivity 4 to 6 hours after administration, when blood ethanol levels are expected to be close to zero [46], [47], [48].
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It was exciting to see that the loss of CB1 overrides COX-1 deficiency-induced delayed parturition (Figure 5A) and remarkably improves the survival rate of newborn pups (Figure 5B).
The intradermal challenge with peptides in animals previously sensitized with M. leprae induced delayed-type hypersensitivity.
Isoflurane-induced delayed preconditioning on spinal cord ischemia improved histopathological outcomes.
More neurogenic inflammation and mast cell degranulation after VIP than after PACAP38 question these phenomena as causative in PACAP38-induced delayed migraine-like attacks.
Intranasal administration of genetic IL-10 diminished Ag-induced delayed type hypersensitivity reactions in associated with the reduction of Ag-specific proliferation and production of Th1 cytokines in mice (Chun et al., 1999).
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